PFE was treated by Dr. Raoof Rasheed Toma:
Two cases of primary failure of eruption. Primary failure of eruption (PFE) is a rare disease defined as incomplete tooth eruption despite the presence of a clear eruption pathway. Orthodontic extrusion is not feasible in this case because it results in ankylosis of teeth. If a patient is affected by PFE, all teeth distal to the most mesial tooth are also affected by PFE. If a patient is suspected of having PFE, a genetic test for mutation in the PTH1R gene should be recommended prior to any orthodontic treatment to avoid ankylosis and in this case, care should be taken before starting the treatment (Hanisch et. al 2018).