A master’s thesis at the College of Medicine at the University of Karbala discussed the evaluation of inflammatory and fibrotic biomarkers and soluble glycoprotein 130 in male type 2 diabetic patients with or without myocardial infarction.
The study, presented by student Maher Adnan Khalaf, aimed to investigate the role of ADAM-17 in the development of metabolic tissue diseases in type 2 diabetes (T2DM) and myocardial infarction resulting from ischemia, and to see the correlation between the levels of ADAM-17, IL-6, and SGP130. And other vital indicators.
The study concluded that continuous high diabetes causes a reduction in ADAM-17 inhibitory proteins, and as a result, an increase in its activity in cleaving and releasing many inflammatory cytokines, such as interleukin 6, which creates a long-term inflammatory environment.
