A doctoral thesis at the Faculty of Dentistry at the University of Karbala discussed the detection of human papillomavirus in relation to biological behavior using the proliferative marker ki67 and the prognostic marker p53 in papilloma Schneideri by the student Shaima Fadl Mohsen.
The objective of the thesis was to describe the effect of HPV infection, as well as to examine the predictive role of proliferative and proliferative markers in relation to dysplasia across biological behaviors through the use of low and high risk human papilloma virus (PCR) as well as immunohistochemical detection of biomarkers.
The thesis included the selection of 35 paraffin-embedded Schneideroma papillomas from the nasal tract where monoclonal antibodies were used for immunohistochemical staining of the nasal sinus papilloma tissues to detect (Ki-67 and p53). Dako quantitative immunohistochemistry analysis was performed to analyze the results, on the tissues, PCR was performed for HPV serotypes 16/18 and 6/11.
The results showed that proliferative, apoptotic, and viral expression had no significant effect in determining the biological behavior of Schneider’s papillary tumor, taking into account dysplasia.
